Jan-2022 Post-operative recurrence of Crohn’s Disease
Speaker: Prof Matthieu Allez (Université de Paris, France)
This IBD Mirror highlights the high recurrence of Crohn’s disease in the operative phase (up to 50% in 5 years) even in the contemporary monitoring programme. Prof Matthieu postulates that diverse histological and molecular abnormalities at the proximal margin of the surgical specimen are associated with an increase risk of post-operative recurrence. Many genes are upregulated even in endoscopic remitters, suggesting that endoscopic remission is not equal to molecular remission. Surgery does not correspond to a complete resetting of the disease in most patients.
